Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library.

نویسندگان

  • Dik-Lung Ma
  • Daniel Shiu-Hin Chan
  • Guo Wei
  • Hai-Jing Zhong
  • Hui Yang
  • Lai To Leung
  • Elizabeth A Gullen
  • Pauline Chiu
  • Yung-Chi Cheng
  • Chung-Hang Leung
چکیده

Amentoflavone has been identified as a JAK2 inhibitor by structure-based virtual screening of a natural product library. In silico optimization using the DOLPHIN model yielded analogues with enhanced potency against JAK2 activity and HCV activity in cellulo. Molecular modeling and kinetic experiments suggested that the analogues may function as Type II inhibitors of JAK2.

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عنوان ژورنال:
  • Chemical communications

دوره 50 90  شماره 

صفحات  -

تاریخ انتشار 2014